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Study: What is Cannabis Use Disorder and CBD Pharmacology

A phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial by the Clinical Psychopharmacology Unit (University College London, London, UK) reports on Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial



Summary The trial by the Clinical Psychopharmacology Unit focused on “cannabis use disorder” and treatments of 400mg and 800mg of CBD for relief.


“substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe. Therefore, we aimed to identify efficacious doses and eliminate inefficacious doses in a phase 2a trial using an adaptive Bayesian design.” States the Clinical Psychopharmacology Unit

Methodology of CBD THC Study


The trial by the Clinical Psychopharmacology Unit used medical industry standards for the CBD study.


  • a phase 2a,

  • double-blind,

  • placebo-controlled,

  • randomised,

  • adaptive Bayesian dose-finding design to identify efficacious

  • or inefficacious doses at a-priori interim and final analysis stages.


Participants meeting cannabis use disorder criteria from DSM-5 were randomly assigned (1:1:1:1) in the first stage of the trial to 4-week treatment with three different doses of oral cannabidiol (200 mg, 400 mg, or 800 mg) OR matched placebo during a cessation attempt

Read more about this trial is at ClinicalTrials.gov ( NCT02044809) and the EU Clinical Trials Register (2013-000361-36).


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